Effect of β-1,3-1,6-D-glukan (polysaccharide peptide) from miselia ganoderma lucidum extract as antioxidant and antiinflammation towards left ventricular systolic function in cardiometabolic patients

Teguh Aryanugraha, Djanggan Sargowo, Anna Fuji Rahimah

Abstract


Background: Cardiometabolic disease (CMD) describes a metabolic condition often associated with cardiovascular disease. It has been revealed that the Ganoderma lucidum polysaccharide peptide (GLPP) possesses anti-inflammatory and antioxidant qualities.

Objective: This study aimed to find out how GLPP affected oxidative stress, inflammation, and left ventricular function in individuals with cardiometabolic syndrome.

Methods: A multicenter double-blinded randomized controlled trial was carried out. Subjects with cardiometabolic syndrome received either GLPP or a placebo for ninety days. Before taking the initial treatment and one day following the last treatment intake, blood samples were taken from every participant. The enzyme-linked immunosorbent assay was used to evaluate the levels of serum tumor necrosis factor (TNF)-α, interleukin-6 (IL-6), malondialdehyde (MDA), and high-sensitivity-C-Reactive Protein (hs-CRP) while the colorimetric test was used to measure the levels of superoxide dismutase (SOD). Global longitudinal strain (GLS)  and Left ventricle ejection fraction (LVEF) were measured by single echocardiographer expert validation.

Results: The MDA level was decreased in the GLPP treatment group (mean 56.0 ± 71.4 ng/mL to 27.7 ± 12.0 ng/mL, p= 0.023) compared to the control group (mean 39.3 ± 29.2 ng/mL to 38.3 ± 17.7 ng/mL, p= 0.719). However, the SOD level remained constant in the GLPP treatment (mean 122.2 ± 176.1 U/mL to 93.0 ± 40.9 U/mL, p=0.925) instead of significantly declining in the control group (mean 102.0 ± 67.3 U/mL to 64.0 ± 52.0 U/mL, p=0.016). The marker of TNF-α and hsCRP were significantly decreased in all groups (both p<0.05), but IL-6 was only significantly decreased in the control group (mean 1149.3 ± 581.7 pg/mL to 744.8 ± 336.5 pg/mL, p=0.010). The GLS was significantly decreased in the GLPP treatment group (-16.1 ± 4.1 to -17.5 ± 4.8, p=0.048) but there was no difference in LVEF in both groups (p>0.05).

Conclusion: Patients with cardiometabolic syndrome may benefit from GLPP treatment for 90 days in terms of reduced inflammation, oxidative stress, and improved systolic left ventricular performance.

Keywords


oxidative stress, inflammation, cardiometabolic syndrome, echocardiography, Ganoderma lucidum

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References


Banez MJ, Geluz MI, Chandra A, et al. A systemic review on the antioxidant and anti-inflammatory effects of resveratrol, curcumin, and dietary nitric oxide supplementation on human cardiovascular health. Nutr Res 2020;78:11–26. https://doi.org/10.1016/j.nutres.2020.03.002. 10.1016/j.nutres.2020.03.002

Schiattarella GG, Rodolico D, Hill JA. Metabolic inflammation in heart failure with preserved ejection fraction. 2021;423–34. 10.1093/cvr/cvaa217

Taleb A, Ahmad KA, Ihsan AU, et al. Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases. Biomed. Pharmacother. 2018;102:689–98. 10.1016/j.biopha.2018.03.140

Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444(7121):860–7. 10.1038/nature05485

Sargowo D, Ovianti N, Susilowati E, et al. The role of polysaccharide peptide of Ganoderma lucidum as a potent antioxidant against atherosclerosis in high risk and stable angina patients. Indian Heart J 2018;70(5):608–14. 10.1016/j.ihj.2017.12.007

Ahmad MF. Ganoderma lucidum: Persuasive biologically active constituents and their health endorsement. Biomed Pharmacother 2018;107(August):507–19. https://doi.org/10.1016/j.biopha.2018.08.036. 10.1016/j.biopha.2018.08.036

Seweryn E, Ziała A, Gamian A. Health-promoting of polysaccharides extracted from ganoderma lucidum. Nutrients 2021;13(8). 10.3390/nu13082725

Huang PL. A comprehensive definition for metabolic syndrome. DMM Dis Model Mech 2009;2(5–6):231–7. 10.1242/dmm.001180

Prasetya I, Ashriyah R, Setyawati I, et al. Polysaccharide Peptide: A promising Anti Inflammation and Anti Oxidant in Atherosclerosis. Indones J Cardiol 2015;36(1):22–7. 10.30701/ijc.v36i1.437

Shaher F, Wang S, Qiu H, et al. Effect and mechanism of Ganoderma lucidum spores on alleviation of diabetic cardiomyopathy in a pilot in vivo study. Diabetes, Metab Syndr Obes 2020;13:4809–22. 10.2147/DMSO.S281527

Rizal A, Sandra F, Fadlan MR, Sargowo D. Ganoderma lucidum Polysaccharide Peptide Reduce Inflammation and Oxidative Stress in Patient with Atrial Fibrillation. Indones Biomed J 2020;12(4):384–9. 10.18585/INABJ.V12I4.1244

Sargowo D, Wihastuti TA, Sukotjo CT, Anjani PM, Handayani O, Adrian LH. The effect of polysaccharides peptides ganoderma lucidum to aortic foam cell count and lipid profile in type 2 diabetic model Rattus norvegicus strain Wistar. Indones Biomed J 2017;9(3):153–9. 10.18585/inabj.v9i3.298

Farikh A. Pemberian Peptida Polisakarida (Psp) Suatu Senyawa Aktif Dari Ganoderma Lucidum (Β-D-Glucan) Berpengaruh Terhadap Dislipidemia Dan Inflamasi Pada Pasien Resiko Tinggi Penyakit Jantung Koroner. Care J Ilm Ilmu Kesehat 2017;(Vol 5, No 1 (2017)):102–11. https://jurnal.unitri.ac.id/index.php/care/article/view/395.

Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore powder of Ganoderma lucidum improves cancer-related fatigue in breast cancer patients undergoing endocrine therapy: A pilot clinical trial. Evidence-based Complement Altern Med 2012;2012. 10.1155/2012/809614

Kao PF, Wang SH, Hung WT, Liao YH, Lin CM, Yang W Bin. Structural characterization and antioxidative activity of low-molecular-weights beta-1,3-glucan from the residue of extracted Ganoderma lucidum fruiting bodies. J Biomed Biotechnol 2012;2012:3–10. 10.1155/2012/673764

Cosyns B, Edvardsen T, Hristova K, Kim H-K. Left ventricle: systolic function. EACVI Textb Echocardiogr 2016;131–46. https://doi.org/10.1093/med/9780198726012.001.0001.

Chakraborti S, Dhalla NS, Dikshit M, Ganguly NK. Modulation of Oxidative Stress in Heart Disease. 2019. 10.1007/978-981-13-8946-7

Meng J, Ma A, Zhang S, et al. Ganoderma Lucidum Polysaccharide Peptide attenuates post myocardial infarction fibrosis via down-regulating TGF-β1/SMAD and relieving oxidative stress. Pharmacol Res - Mod Chinese Med 2022;4(August):100152. https://doi.org/10.1016/j.prmcm.2022.100152. 10.1016/j.prmcm.2022.100152




DOI: https://doi.org/10.21776/ub.hsj.2024.005.04.9

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