The role of colchicine on ventricular remodelling following myocardial infarction and ischemia-reperfusion injury: article review

Authors

  • Fahreza Caesario Cardiology Resident, Brawijaya Universty
  • Indra Prasetya Department of Cardiology and Vascular Medicine
– Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia

DOI:

https://doi.org/10.21776/ub.hsj.2024.005.04.3

Keywords:

Colchicine, Ischemia-Reperfusion Injury, Myocardial Infarction Ventricular Remodelling

Abstract

Acute myocardial infarction (AMI) is a major cause of cardiac dysfunction, arrhythmias, and a poor prognosis. Even though new technologies have been developed to aid in opening the culprit coronary artery and correcting ischemia-related stenosis by percutaneous coronary intervention (PCI), the ventricular remodelling that induces cardiac failure as a consequence of AMI remains unchanged. Colchicine, a versatile anti-inflammatory medication, has been documented in mitigating cardiac remodelling and enhancing cardiac function following AMI. This article provides an in-depth review of the processes by which colchicine affects ventricular remodeling after AMI, highlighting the potential role of inflammation in the pathogenesis and progression of ventricular dysfunction.

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Published

2024-10-28