Early Detection of Congenital Heart Disease in Pregnant Young Women at Risk

Authors

DOI:

https://doi.org/10.21776/ub.hsj.2022.003.03.1

Keywords:

Congenital Heart Defect, Pregnancy, Screening, Diagnosis, Clinical Predictors

Abstract

Cardiovascular disease (CVD) is one of the non-communicable diseases in which the leading cause of death worldwide at 48%1. CVD contains a spectrum of diseases, one of which is Congenital Heart Defect (CHD). CHD is one of the contributors to morbidity from young until adulthood. The advancement of surgical correction and medical therapy made it possible for early structural correction, as uncorrected CHD while patients were still young posed a risk of health outcome deterioration later in life. CHD affected especially pregnant individuals. A pregnant woman diagnosed with CHD would often complain of significantly significant deterioration of health condition and quality of life as they have a higher susceptibility to cardiovascular complications than women in general. Pregnant women diagnosed with CHD in developing countries more often presented with signs indicating complications of CHD, such as Eisenmenger syndrome, signs of heart failure, Pulmonary Hypertension (PH), cyanosis, and NYHA functional classes II and III, which indicate later diagnosis and treatment further into adulthood in these patients. Lack of expertise and facility for diagnosis of CHD posed a major challenge in reducing mortality related to CHD in these countries. Therefore the need for a screening method at least for directing further referral to major health centers is still in high demand.

References

World Health Organization. Cardiovascular diseases [Internet]. [cited 2022 Jun 25];Available from: https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1

Gilboa SM, Devine OJ, Kucik JE, et al. Congenital heart defects in the United States: estimating the magnitude of the affected population in 2010. Circulation 2016;134(2):101–9.

World Health Organization. Adolescent health in the South-East Asia Region [Internet]. WHO. [cited 2022 Jun 25]; Available from: https://www.who.int/southeastasia/health-topics/adolescent-health

Wu W, He J, Shao X. Incidence and mortality trend of congenital heart disease at the global, regional, and national level, 1990-2017. Medicine (Baltimore) 2020;99(23):e20593–e20593.

Grandi SM, Filion KB, Yoon S, et al. Cardiovascular disease-related morbidity and mortality in women with a history of pregnancy complications: systematic review and meta-analysis. Circulation 2019;139(8):1069–79.

Niwa K. Adult Congenital Heart Disease with Pregnancy. Korean Circ J 2018;48(4):251–76.

Sanghavi M, Rutherford JD. Cardiovascular Physiology of Pregnancy. Circulation 2014;130(12):1003–8.

Sliwa K, Baris L, Sinning C, et al. Pregnant women with uncorrected congenital heart disease: heart failure and mortality. JACC Heart Fail 2020;8(2):100–10.

Baumgartner H, De Backer J, Babu-Narayan SV, et al. 2020 ESC Guidelines for the management of adult congenital heart disease: The Task Force for the management of adult congenital heart disease of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Adult Congenital Heart Disease (ISACHD). Eur Heart J 2021;42(6):563–645.

Prakash A, Powell AJ, Geva T. Multimodality Noninvasive Imaging for Assessment of Congenital Heart Disease. Circ Cardiovasc Imaging 2010;3(1):112–25.

Rakha S, El Marsafawy H. Sensitivity, specificity, and accuracy of fetal echocardiography for high-risk pregnancies in a tertiary center in Egypt. Arch Pédiatrie 2019;26(6):337–41.

Endorsed by the European Society of Gynecology (ESG) the A for EPC (AEPC) and the German Society for Gender Medicine (DGesGM), Authors/Task Force Members, Regitz-Zagrosek V, et al. ESC Guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC). Eur Heart J 2011;32(24):3147–97.

Silversides CK, Grewal J, Mason J, et al. Pregnancy Outcomes in Women With Heart Disease: The CARPREG II Study. J Am Coll Cardiol 2018;71(21):2419–30.

Drenthen W, Boersma E, Balci A, et al. Predictors of pregnancy complications in women with congenital heart disease. Eur Heart J 2010;31(17):2124–32.

Izhar FM, Abqari S, Shahab T, Ali SM. A clinical score to detect congenital heart defects: Concept of second screening. Ann Pediatr Cardiol 2020;13(4):281–8.

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Published

2022-07-28